Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs

The protein kinase Gcn2 is a central transducer of nutritional stress signaling important for stress adaptation by normal cells and the survival of cancer cells. In response to nutrient deprivation, Gcn2 phosphorylates eIF2α, thereby repressing general translation while enhancing translation of spec...

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Detalles Bibliográficos
Autores principales: Chikashige, Yuji, Kato, Hiroaki, Thornton, Mackenzie, Pepper, Whitney, Hilgers, Madelyn, Cecil, Ariana, Asano, Izumi, Yamada, Haana, Mori, Chie, Brunkow, Cheyenne, Moravek, Carter, Urano, Takeshi, Singh, Chingakham Ranjit, Asano, Katsura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498311/
https://www.ncbi.nlm.nih.gov/pubmed/32710633
http://dx.doi.org/10.1093/nar/gkaa608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498311/
https://www.ncbi.nlm.nih.gov/pubmed/32710633
http://dx.doi.org/10.1093/nar/gkaa608

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