Microcephaly family protein MCPH1 stabilizes RAD51 filaments

Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with primary autosomal recessive microcephaly. In response to DNA double-strand breaks (DSBs), MCPH1 forms damage-induced foci and recruits BRCA2–RAD51 complex, a key component of the DSB repair machinery for homologous recomb...

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Detalles Bibliográficos
Autores principales: Chang, Hao-Yen, Lee, Chia-Yi, Lu, Chih-Hao, Lee, Wei, Yang, Han-Lin, Yeh, Hsin-Yi, Li, Hung-Wen, Chi, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498314/
https://www.ncbi.nlm.nih.gov/pubmed/32735676
http://dx.doi.org/10.1093/nar/gkaa636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498314/
https://www.ncbi.nlm.nih.gov/pubmed/32735676
http://dx.doi.org/10.1093/nar/gkaa636

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