Nucleosomes effectively shield DNA from radiation damage in living cells

Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair. Here, we show that in living cells nucleosomes protect DNA from high-energy radiation and reactive oxygen species. We combined sequence-based methods...

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Detalles Bibliográficos
Autores principales: Brambilla, Francesca, Garcia-Manteiga, Jose Manuel, Monteleone, Emanuele, Hoelzen, Lena, Zocchi, Angelica, Agresti, Alessandra, Bianchi, Marco E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498322/
https://www.ncbi.nlm.nih.gov/pubmed/32710624
http://dx.doi.org/10.1093/nar/gkaa613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498322/
https://www.ncbi.nlm.nih.gov/pubmed/32710624
http://dx.doi.org/10.1093/nar/gkaa613

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