Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity

DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer drugs that poison the DNA-TOP2 transient complex to generate TOP2-linked DNA dou...

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Detalles Bibliográficos
Autores principales: Olmedo-Pelayo, Joaquín, Rubio-Contreras, Diana, Gómez-Herreros, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498328/
https://www.ncbi.nlm.nih.gov/pubmed/32749454
http://dx.doi.org/10.1093/nar/gkaa640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498328/
https://www.ncbi.nlm.nih.gov/pubmed/32749454
http://dx.doi.org/10.1093/nar/gkaa640

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