Cargando…

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity

DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer drugs that poison the DNA-TOP2 transient complex to generate TOP2-linked DNA dou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olmedo-Pelayo, Joaquín, Rubio-Contreras, Diana, Gómez-Herreros, Fernando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498328/ https://www.ncbi.nlm.nih.gov/pubmed/32749454 http://dx.doi.org/10.1093/nar/gkaa640

Ejemplares similares

End-processing during non-homologous end-joining: a role for exonuclease 1
por: Bahmed, Karim, et al.
Publicado: (2011)

Lif1 SUMOylation and its role in non-homologous end-joining
por: Vigasova, Dana, et al.
Publicado: (2013)

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
por: Beck, Carole, et al.
Publicado: (2014)

A role for human homologous recombination factors in suppressing microhomology-mediated end joining
por: Ahrabi, Sara, et al.
Publicado: (2016)

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells
por: Renouf, Benjamin, et al.
Publicado: (2012)

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
por: Iiizumi, Susumu, et al.
Publicado: (2008)

Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity
por: Kirkman, Laura A., et al.
Publicado: (2014)

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
por: Öz, Robin, et al.
Publicado: (2021)

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks
por: Hatkevich, Talia, et al.
Publicado: (2021)

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
por: Zong, Dali, et al.
Publicado: (2015)

Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining
por: Liang, Zhuobin, et al.
Publicado: (2016)

USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing
por: Kim, Jae Jin, et al.
Publicado: (2021)

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining
por: Lu, Huiming, et al.
Publicado: (2023)

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining
por: Soni, Aashish, et al.
Publicado: (2014)

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF
por: Jessulat, Matthew, et al.
Publicado: (2021)

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
por: Head, PamelaSara E, et al.
Publicado: (2023)

SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining
por: Jaafar, Lahcen, et al.
Publicado: (2017)

H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions
por: Feng, Yi-Li, et al.
Publicado: (2017)

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
por: Muñoz-Galván, Sandra, et al.
Publicado: (2013)

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
por: Quennet, Verena, et al.
Publicado: (2011)

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation
por: Shen, Mengyu, et al.
Publicado: (2018)

Proximal binding of dCas9 at a DNA double strand break stimulates homology-directed repair as a local inhibitor of classical non-homologous end joining
por: Feng, Yi-Li, et al.
Publicado: (2023)

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
por: Zhao, Bailin, et al.
Publicado: (2020)

USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells
por: Sharma, Arishya, et al.
Publicado: (2020)

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair
por: Yang, Linlin, et al.
Publicado: (2021)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells
por: Covo, Shay, et al.
Publicado: (2009)

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining
por: Zhu, Songli, et al.
Publicado: (2017)

MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1
por: Oh, Jung-Min, et al.
Publicado: (2023)

XRCC4's interaction with XLF is required for coding (but not signal) end joining
por: Roy, Sunetra, et al.
Publicado: (2012)

Control of alternative end joining by the chromatin remodeler p400 ATPase
por: Taty-Taty, Gemael-Cedrick, et al.
Publicado: (2016)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins
por: de Ory, Ana, et al.
Publicado: (2014)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

PLK1 targets CtIP to promote microhomology-mediated end joining
por: Wang, Hailong, et al.
Publicado: (2018)

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
por: Yu, Amy Marie, et al.
Publicado: (2010)

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

53BP1 promotes microhomology-mediated end-joining in G1-phase cells
por: Xiong, Xiahui, et al.
Publicado: (2015)

SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining
por: Akimova, Ekaterina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i3aack5fkn8vnak6gujecuqupp