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CRISPR/Cas9 treatment causes extended TP53-dependent cell cycle arrest in human cells
While the mechanism of CRISPR/Cas9 cleavage is understood, the basis for the large variation in mutant recovery for a given target sequence between cell lines is much less clear. We hypothesized that this variation may be due to differences in how the DNA damage response affects cell cycle progressi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498335/ https://www.ncbi.nlm.nih.gov/pubmed/32687165 http://dx.doi.org/10.1093/nar/gkaa603 |