Location specific annealing of miR-122 and other small RNAs defines an Hepatitis C Virus 5′ UTR regulatory element with distinct impacts on virus translation and genome stability

Hepatitis C virus (HCV) replication requires annealing of a liver specific small-RNA, miR-122 to 2 sites on 5′ untranslated region (UTR). Annealing has been reported to (a) stabilize the genome, (b) stimulate translation and (c) promote the formation of translationally active Internal Ribosome Entry...

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Detalles Bibliográficos
Autores principales: Kunden, Rasika D, Ghezelbash, Sarah, Khan, Juveriya Q, Wilson, Joyce A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498337/
https://www.ncbi.nlm.nih.gov/pubmed/32810257
http://dx.doi.org/10.1093/nar/gkaa664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498337/
https://www.ncbi.nlm.nih.gov/pubmed/32810257
http://dx.doi.org/10.1093/nar/gkaa664

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