Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant

Substitutions in the exonuclease domain of DNA polymerase ϵ cause ultramutated human tumors. Yeast and mouse mimics of the most common variant, P286R, produce mutator effects far exceeding the effect of Polϵ exonuclease deficiency. Yeast Polϵ-P301R has increased DNA polymerase activity, which could...

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Detalles Bibliográficos
Autores principales: Bulock, Chelsea R, Xing, Xuanxuan, Shcherbakova, Polina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498342/
https://www.ncbi.nlm.nih.gov/pubmed/32756902
http://dx.doi.org/10.1093/nar/gkaa633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498342/
https://www.ncbi.nlm.nih.gov/pubmed/32756902
http://dx.doi.org/10.1093/nar/gkaa633

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