The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2

The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor suppressor. However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown. Here, we showed that SIRT6 was recruited t...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Anke, Tang, Huanyin, Huang, Jin, Qian, Zhen, Qin, Nan, Yao, Yunxia, Xu, Zhu, Chen, Hao, Lan, Li, Xie, Hongjuan, Zhang, Jian, Jiang, Ying, Mao, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498349/
https://www.ncbi.nlm.nih.gov/pubmed/32789493
http://dx.doi.org/10.1093/nar/gkaa661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498349/
https://www.ncbi.nlm.nih.gov/pubmed/32789493
http://dx.doi.org/10.1093/nar/gkaa661

Ejemplares similares