Enhanced YB1/EphA2 axis signaling promotes acquired resistance to sunitinib and metastatic potential in renal cell carcinoma

VHL mutations are the most common tumorigenic lesions in clear cell renal cell carcinoma (ccRCC) and result in continued activation of the HIF/VEGF pathway and uncontrolled cancer progression. Receptor tyrosine kinase (RTK) inhibitors such as sunitinib have been demonstrated to target tumorigenic si...

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Detalles Bibliográficos
Autores principales: Ruan, Hailong, Li, Sen, Bao, Lin, Zhang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498371/
https://www.ncbi.nlm.nih.gov/pubmed/32814829
http://dx.doi.org/10.1038/s41388-020-01409-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498371/
https://www.ncbi.nlm.nih.gov/pubmed/32814829
http://dx.doi.org/10.1038/s41388-020-01409-6

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