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Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation

Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells proved to be hyper-responsive to CD3/CD28 co-stimulation, in...

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Detalles Bibliográficos
Autores principales:	De Lira, Maria Nathalia, Raman, Sudha Janaki, Schulze, Almut, Schneider-Schaulies, Sibylle, Avota, Elita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498697/ https://www.ncbi.nlm.nih.gov/pubmed/33088808 http://dx.doi.org/10.3389/fmolb.2020.00217

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