A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m(6)A Methyltransferase Component METTL14 in T Cells

BACKGROUND AND AIMS: Mouse models of colitis have been used to study the pathogenesis of inflammatory bowel disease (IBD) and for pre-clinical development of therapeutic agents. Various epigenetic pathways have been shown to play important regulatory roles in IBD. Reversible N(6)-methyladenosine (m(...

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Detalles Bibliográficos
Autores principales: Lu, Thomas X., Zheng, Zhong, Zhang, Linda, Sun, Hui-Lung, Bissonnette, Marc, Huang, Haochu, He, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498954/
https://www.ncbi.nlm.nih.gov/pubmed/32634481
http://dx.doi.org/10.1016/j.jcmgh.2020.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498954/
https://www.ncbi.nlm.nih.gov/pubmed/32634481
http://dx.doi.org/10.1016/j.jcmgh.2020.07.001

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