A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics

Monoclonal antibodies (mAbs) can be engineered to have “extended half‐life” and “catch and release” properties to improve target coverage. We have developed a mAb physiologically‐based pharmacokinetic model that describes intracellular trafficking, neonatal Fc receptor (FcRn) recycling, and nonspeci...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Hannah M., Tolsma, John, Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Weber, Gregory L., Wright, Katherine, Bard, Joel, Bell, Robert, Messing, Dean, Kelleher, Kerry, Piche‐Nicholas, Nicole, Webster, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499188/
https://www.ncbi.nlm.nih.gov/pubmed/32697437
http://dx.doi.org/10.1002/psp4.12547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499188/
https://www.ncbi.nlm.nih.gov/pubmed/32697437
http://dx.doi.org/10.1002/psp4.12547

Ejemplares similares