Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury

Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1’s cysteine residues. Here, we tested the potential effect of 4-OI on hydrogen peroxide (H(2)O(2))-induced oxidative injury in osteoblasts. In OB-6 cells and primary murine o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Yuehuan, Chen, Zhe, She, Chang, Lin, Yazhou, Hong, Yuan, Shi, Liqiang, Zhang, Yingzi, Cao, Peng, Xu, Xiangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499214/
https://www.ncbi.nlm.nih.gov/pubmed/32943614
http://dx.doi.org/10.1038/s41419-020-02987-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499214/
https://www.ncbi.nlm.nih.gov/pubmed/32943614
http://dx.doi.org/10.1038/s41419-020-02987-9

Ejemplares similares