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Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury

Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1’s cysteine residues. Here, we tested the potential effect of 4-OI on hydrogen peroxide (H(2)O(2))-induced oxidative injury in osteoblasts. In OB-6 cells and primary murine o...

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Detalles Bibliográficos
Autores principales:	Zheng, Yuehuan, Chen, Zhe, She, Chang, Lin, Yazhou, Hong, Yuan, Shi, Liqiang, Zhang, Yingzi, Cao, Peng, Xu, Xiangyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499214/ https://www.ncbi.nlm.nih.gov/pubmed/32943614 http://dx.doi.org/10.1038/s41419-020-02987-9

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