Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully us...

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Detalles Bibliográficos
Autores principales: Shannon, Ashleigh, Selisko, Barbara, Le, Nhung-Thi-Tuyet, Huchting, Johanna, Touret, Franck, Piorkowski, Géraldine, Fattorini, Véronique, Ferron, François, Decroly, Etienne, Meier, Chris, Coutard, Bruno, Peersen, Olve, Canard, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499305/
https://www.ncbi.nlm.nih.gov/pubmed/32943628
http://dx.doi.org/10.1038/s41467-020-18463-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499305/
https://www.ncbi.nlm.nih.gov/pubmed/32943628
http://dx.doi.org/10.1038/s41467-020-18463-z

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