Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP

Neurodegenerative mechanisms due to mutations in spastin currently center on neuronal defects, primarily in microtubule and endomembrane regulation. Spastin loss in Drosophila larvae compromises neuronal microtubule distribution, alters synaptic bouton morphology, and weakens synaptic transmission a...

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Detalles Bibliográficos
Autores principales: Ozdowski, Emily F., Wentzell, Jill S., Engert, Stefanie M., Abbott, Helena, Sherwood, Nina T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499821/
https://www.ncbi.nlm.nih.gov/pubmed/33013303
http://dx.doi.org/10.3389/fnins.2020.00912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499821/
https://www.ncbi.nlm.nih.gov/pubmed/33013303
http://dx.doi.org/10.3389/fnins.2020.00912

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