High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

BACKGROUND: Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membrane and the extracellular matrix. Overexpression of sarcospan (SSPN) in the mouse...

Descripción completa

Detalles Bibliográficos
Autores principales: Shu, Cynthia, Parfenova, Liubov, Mokhonova, Ekaterina, Collado, Judd R., Damoiseaux, Robert, Campagna, Jesus, John, Varghese, Crosbie, Rachelle H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499884/
https://www.ncbi.nlm.nih.gov/pubmed/32948250
http://dx.doi.org/10.1186/s13395-020-00244-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499884/
https://www.ncbi.nlm.nih.gov/pubmed/32948250
http://dx.doi.org/10.1186/s13395-020-00244-3

Ejemplares similares