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High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy
BACKGROUND: Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membrane and the extracellular matrix. Overexpression of sarcospan (SSPN) in the mouse...
Autores principales: | Shu, Cynthia, Parfenova, Liubov, Mokhonova, Ekaterina, Collado, Judd R., Damoiseaux, Robert, Campagna, Jesus, John, Varghese, Crosbie, Rachelle H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499884/ https://www.ncbi.nlm.nih.gov/pubmed/32948250 http://dx.doi.org/10.1186/s13395-020-00244-3 |
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