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Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

BACKGROUND: Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any benefit...

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Detalles Bibliográficos
Autores principales: Braun, David J., Dimayuga, Edgardo, Morganti, Josh M., Van Eldik, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499995/
https://www.ncbi.nlm.nih.gov/pubmed/32943069
http://dx.doi.org/10.1186/s12974-020-01938-7