Genome scale analysis of pathogenic variants targetable for single base editing

BACKGROUND: Single nucleotide variants account for approximately 90% of all known pathogenic variants responsible for human diseases. Recently discovered CRISPR/Cas9 base editors can correct individual nucleotides without cutting DNA and inducing double-stranded breaks. We aimed to find all possible...

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Detalles Bibliográficos
Autores principales: Lavrov, Alexander V., Varenikov, Georgi G., Skoblov, Mikhail Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499999/
https://www.ncbi.nlm.nih.gov/pubmed/32948190
http://dx.doi.org/10.1186/s12920-020-00735-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499999/
https://www.ncbi.nlm.nih.gov/pubmed/32948190
http://dx.doi.org/10.1186/s12920-020-00735-8

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