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Genome scale analysis of pathogenic variants targetable for single base editing
BACKGROUND: Single nucleotide variants account for approximately 90% of all known pathogenic variants responsible for human diseases. Recently discovered CRISPR/Cas9 base editors can correct individual nucleotides without cutting DNA and inducing double-stranded breaks. We aimed to find all possible...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499999/ https://www.ncbi.nlm.nih.gov/pubmed/32948190 http://dx.doi.org/10.1186/s12920-020-00735-8 |