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Generation of induced neural stem cells with inducible IDH1(R132H) for analysis of glioma development and drug testing
Mutation in isocitrate dehydrogenase 1 (IDH1(R132H)) occurs in various types of cancer, including low and high grade gliomas. Despite high incidence indicating its central role in tumor initiation and progression there are no targeted therapies directed against this oncogene available in the clinic....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500637/ https://www.ncbi.nlm.nih.gov/pubmed/32946483 http://dx.doi.org/10.1371/journal.pone.0239325 |