Cargando…
Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection
Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and activates innate immune responses via stimulator of interferon genes (STING), but the impact of DNA sensing pathways on host protective responses has not been full...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500930/ https://www.ncbi.nlm.nih.gov/pubmed/32948585 http://dx.doi.org/10.1126/sciadv.abb4565 |