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Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection

Cells contain numerous immune sensors to detect virus infection. The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and activates innate immune responses via stimulator of interferon genes (STING), but the impact of DNA sensing pathways on host protective responses has not been full...

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Detalles Bibliográficos
Autores principales:	Hernáez, Bruno, Alonso, Graciela, Georgana, Iliana, El-Jesr, Misbah, Martín, Rocío, Shair, Kathy H. Y., Fischer, Cornelius, Sauer, Sascha, Maluquer de Motes, Carlos, Alcamí, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500930/ https://www.ncbi.nlm.nih.gov/pubmed/32948585 http://dx.doi.org/10.1126/sciadv.abb4565

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