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Click chemistry compared to thiol chemistry for the synthesis of site-selective glycoconjugate vaccines using CRM(197) as carrier protein
Conjugation chemistry is one of the main parameters affecting immunogenicity of glycoconjugate vaccines and a rational approach toward a deeper understanding of their mechanism of action will greatly benefit from highly-defined and well-characterized structures. Herein, different conjugation methods...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501094/ https://www.ncbi.nlm.nih.gov/pubmed/32535667 http://dx.doi.org/10.1007/s10719-020-09930-2 |