TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

Centrosomes catalyze microtubule formation for mitotic spindle assembly(1). Centrosomes duplicate once per cell cycle in a process controlled the kinase PLK4(2,3). Following chemical PLK4 inhibition, cell division in the absence of centrosome duplication generates centrosome-less cells that exhibit...

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Detalles Bibliográficos
Autores principales: Meitinger, Franz, Ohta, Midori, Lee, Kian-Yong, Watanabe, Sadanori, Davis, Robert L., Anzola, John V., Kabeche, Ruth, Jenkins, David, Shiau, Andrew K., Desai, Arshad, Oegema, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501188/
https://www.ncbi.nlm.nih.gov/pubmed/32908304
http://dx.doi.org/10.1038/s41586-020-2710-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501188/
https://www.ncbi.nlm.nih.gov/pubmed/32908304
http://dx.doi.org/10.1038/s41586-020-2710-1

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