Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selectively replace protons with deuterium atoms. With the goal of achieving controllable isotope-...

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Detalles Bibliográficos
Autores principales: Zhang, Zhaofei, Qiu, Chuntian, Xu, Yangsen, Han, Qing, Tang, Junwang, Loh, Kian Ping, Su, Chenliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501254/
https://www.ncbi.nlm.nih.gov/pubmed/32948764
http://dx.doi.org/10.1038/s41467-020-18458-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501254/
https://www.ncbi.nlm.nih.gov/pubmed/32948764
http://dx.doi.org/10.1038/s41467-020-18458-w

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