Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways

Cisplatin (CP) is a powerful antineoplastic chemotherapeutic agent with broad-spectrum properties. Acute and cumulative cardiotoxicity are major limiting factors for CP therapy. Various pathogenic pathways have been suggested to CP-induced cardiotoxicity; oxidative damage, ER stress, and programmed...

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Detalles Bibliográficos
Autores principales: Saleh, Dalia O., Mansour, Dina F., Mostafa, Rasha E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501485/
https://www.ncbi.nlm.nih.gov/pubmed/32995293
http://dx.doi.org/10.1016/j.toxrep.2020.08.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501485/
https://www.ncbi.nlm.nih.gov/pubmed/32995293
http://dx.doi.org/10.1016/j.toxrep.2020.08.026

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