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Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins

The canonical function of Bcl-2 family proteins is to regulate mitochondrial membrane integrity. In response to apoptotic signals the multi-domain pro-apoptotic proteins Bax and Bak are activated and perforate the mitochondrial outer membrane by a mechanism which is inhibited by their interaction wi...

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Detalles Bibliográficos
Autores principales: Lindenboim, Liora, Grozki, Dan, Amsalem-Zafran, Ayelet R., Peña-Blanco, Aida, Gundersen, Gregg G., Borner, Christoph, Hodzic, Didier, Garcia-Sáez, Ana J., Worman, Howard J., Stein, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501853/
https://www.ncbi.nlm.nih.gov/pubmed/33024575
http://dx.doi.org/10.1038/s41420-020-00327-6