Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression

When drugs exert their effects in the brain, linear extrapolation of doses from adults could be harmful for children as the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB) function is still immature. More specifically, age-related variation in membrane transporters may impact brain dispositi...

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Detalles Bibliográficos
Autores principales: Verscheijden, L. F. M., van Hattem, A. C., Pertijs, J. C. L. M., de Jongh, C. A., Verdijk, R. M., Smeets, B., Koenderink, J. B., Russel, F. G. M., de Wildt, S. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502061/
https://www.ncbi.nlm.nih.gov/pubmed/32448916
http://dx.doi.org/10.1007/s00418-020-01884-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502061/
https://www.ncbi.nlm.nih.gov/pubmed/32448916
http://dx.doi.org/10.1007/s00418-020-01884-8

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