Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression

Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In this study, we determined the effect of relatively s...

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Detalles Bibliográficos
Autores principales: Caiment, F., Wolters, J., Smit, E., Schrooders, Y., Kleinjans, J., van den Beucken, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Molecular Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502062/
https://www.ncbi.nlm.nih.gov/pubmed/32623605
http://dx.doi.org/10.1007/s00204-020-02835-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502062/
https://www.ncbi.nlm.nih.gov/pubmed/32623605
http://dx.doi.org/10.1007/s00204-020-02835-x

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