Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia

Genetic mechanisms underlying age-related cognitive decline and dementia remain poorly understood. Here, we take advantage of the Diversity Outbred mouse population to utilize quantitative trait loci mapping and identify Dlgap2 as a positional candidate responsible for modifying working memory decli...

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Detalles Bibliográficos
Autores principales: Ouellette, Andrew R., Neuner, Sarah M., Dumitrescu, Logan, Anderson, Laura C., Gatti, Daniel M., Mahoney, Emily R., Bubier, Jason A., Churchill, Gary, Peters, Luanne, Huentelman, Matthew J., Herskowitz, Jeremy H., Yang, Hyun-Sik, Smith, Alexandra N., Reitz, Christiane, Kunkle, Brian W., White, Charles C., De Jager, Philip L., Schneider, Julie A., Bennett, David A., Seyfried, Nicholas T., Chesler, Elissa J., Hadad, Niran, Hohman, Timothy J., Kaczorowski, Catherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175/
https://www.ncbi.nlm.nih.gov/pubmed/32877673
http://dx.doi.org/10.1016/j.celrep.2020.108091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175/
https://www.ncbi.nlm.nih.gov/pubmed/32877673
http://dx.doi.org/10.1016/j.celrep.2020.108091

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