AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication

AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a sensor of endoplasmic reticulum stress and is an essential chaperone required for the life cycle of all mammalian viruses....

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Detalles Bibliográficos
Autores principales: Rayner, Jonathan O., Roberts, Rosemary A., Kim, Jin, Poklepovic, Andrew, Roberts, Jane L., Booth, Laurence, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502229/
https://www.ncbi.nlm.nih.gov/pubmed/32966814
http://dx.doi.org/10.1016/j.bcp.2020.114227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502229/
https://www.ncbi.nlm.nih.gov/pubmed/32966814
http://dx.doi.org/10.1016/j.bcp.2020.114227

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