Cargando…
AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a sensor of endoplasmic reticulum stress and is an essential chaperone required for the life cycle of all mammalian viruses....
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502229/ https://www.ncbi.nlm.nih.gov/pubmed/32966814 http://dx.doi.org/10.1016/j.bcp.2020.114227 |