Genome scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, raising the prospect of a cell replacement therapy for T1D. However, autoimmunity would rapidly destroy newly transplanted beta cells. Using a gen...

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Detalles Bibliográficos
Autores principales: Cai, Erica P., Ishikawa, Yuki, Zhang, Wei, Leite, Nayara C., Li, Jian, Hou, Shurong, Kiaf, Badr, Hollister-Lock, Jennifer, Yilmaz, Nese Kurt, Schiffer, Celia A., Melton, Douglas A., Kissler, Stephan, Yi, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502486/
https://www.ncbi.nlm.nih.gov/pubmed/32719542
http://dx.doi.org/10.1038/s42255-020-0254-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502486/
https://www.ncbi.nlm.nih.gov/pubmed/32719542
http://dx.doi.org/10.1038/s42255-020-0254-1

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