Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intra-tumoral stromagenesis

Activation of cancer-associated fibroblasts (CAFs) and ensuing desmoplasia play an important role in the growth and progression of solid tumors. Here we demonstrate that, within colon and pancreatic ductal adenocarcinoma tumors, efficient stromagenesis relies on downregulation of the IFNAR1 chain of...

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Detalles Bibliográficos
Autores principales: Cho, Christina, Mukherjee, Riddhita, Peck, Amy R., Sun, Yunguang, McBrearty, Noreen, Katlinski, Kanstantsin V., Gui, Jun, Govindaraju, Priya K., Puré, Ellen, Rui, Hallgeir, Fuchs, Serge Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502515/
https://www.ncbi.nlm.nih.gov/pubmed/32807917
http://dx.doi.org/10.1038/s41388-020-01424-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502515/
https://www.ncbi.nlm.nih.gov/pubmed/32807917
http://dx.doi.org/10.1038/s41388-020-01424-7

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