The cryoelectron microscopy structure of the human CDK-activating kinase

The human CDK-activating kinase (CAK), a complex composed of cyclin-dependent kinase (CDK) 7, cyclin H, and MAT1, is a critical regulator of transcription initiation and the cell cycle. It acts by phosphorylating the C-terminal heptapeptide repeat domain of the RNA polymerase II (Pol II) subunit RPB...

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Detalles Bibliográficos
Autores principales: Greber, Basil J., Perez-Bertoldi, Juan M., Lim, Kif, Iavarone, Anthony T., Toso, Daniel B., Nogales, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502720/
https://www.ncbi.nlm.nih.gov/pubmed/32855301
http://dx.doi.org/10.1073/pnas.2009627117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502720/
https://www.ncbi.nlm.nih.gov/pubmed/32855301
http://dx.doi.org/10.1073/pnas.2009627117

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