Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers

Enzyme turnover numbers (k(cat)s) are essential for a quantitative understanding of cells. Because k(cat)s are traditionally measured in low-throughput assays, they can be inconsistent, labor-intensive to obtain, and can miss in vivo effects. We use a data-driven approach to estimate in vivo k(cat)s...

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Detalles Bibliográficos
Autores principales: Heckmann, David, Campeau, Anaamika, Lloyd, Colton J., Phaneuf, Patrick V., Hefner, Ying, Carrillo-Terrazas, Marvic, Feist, Adam M., Gonzalez, David J., Palsson, Bernhard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502767/
https://www.ncbi.nlm.nih.gov/pubmed/32873645
http://dx.doi.org/10.1073/pnas.2001562117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502767/
https://www.ncbi.nlm.nih.gov/pubmed/32873645
http://dx.doi.org/10.1073/pnas.2001562117

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