Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer

A number of APOBEC family DNA cytosine deaminases can induce mutations in tumor cells. APOBEC3H haplotype I is one of the deaminases that has been proposed to cause mutations in lung cancer. Here, we confirmed that APOBEC3H haplotype I can cause uracil-induced DNA damage in lung cancer cells that re...

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Detalles Bibliográficos
Autores principales: Hix, Mark A, Wong, Lai, Flath, Ben, Chelico, Linda, Cisneros, G Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Cancer Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503452/
https://www.ncbi.nlm.nih.gov/pubmed/32984821
http://dx.doi.org/10.1093/narcan/zcaa023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503452/
https://www.ncbi.nlm.nih.gov/pubmed/32984821
http://dx.doi.org/10.1093/narcan/zcaa023

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