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The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases
Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin–proteasome system (UPS). The process is regulated by three main types of enzymes, namely ubiquitin-activating enzy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503467/ https://www.ncbi.nlm.nih.gov/pubmed/32882786 http://dx.doi.org/10.3390/ijms21176335 |
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author | Celebi, Gizem Kesim, Hale Ozer, Ebru Kutlu, Ozlem |
author_facet | Celebi, Gizem Kesim, Hale Ozer, Ebru Kutlu, Ozlem |
author_sort | Celebi, Gizem |
collection | PubMed |
description | Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin–proteasome system (UPS). The process is regulated by three main types of enzymes, namely ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Under physiological conditions, ubiquitination is highly reversible reaction, and deubiquitinases or deubiquitinating enzymes (DUBs) can reverse the effect of E3 ligases by the removal of ubiquitin from substrate proteins, thus maintaining the protein quality control and homeostasis in the cell. The dysfunction or dysregulation of these multi-step reactions is closely related to pathogenic conditions; therefore, understanding the role of ubiquitination in diseases is highly valuable for therapeutic approaches. In this review, we first provide an overview of the molecular mechanism of ubiquitination and UPS; then, we attempt to summarize the most common diseases affecting the dysfunction or dysregulation of these mechanisms. |
format | Online Article Text |
id | pubmed-7503467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75034672020-09-23 The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases Celebi, Gizem Kesim, Hale Ozer, Ebru Kutlu, Ozlem Int J Mol Sci Review Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin–proteasome system (UPS). The process is regulated by three main types of enzymes, namely ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). Under physiological conditions, ubiquitination is highly reversible reaction, and deubiquitinases or deubiquitinating enzymes (DUBs) can reverse the effect of E3 ligases by the removal of ubiquitin from substrate proteins, thus maintaining the protein quality control and homeostasis in the cell. The dysfunction or dysregulation of these multi-step reactions is closely related to pathogenic conditions; therefore, understanding the role of ubiquitination in diseases is highly valuable for therapeutic approaches. In this review, we first provide an overview of the molecular mechanism of ubiquitination and UPS; then, we attempt to summarize the most common diseases affecting the dysfunction or dysregulation of these mechanisms. MDPI 2020-09-01 /pmc/articles/PMC7503467/ /pubmed/32882786 http://dx.doi.org/10.3390/ijms21176335 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Celebi, Gizem Kesim, Hale Ozer, Ebru Kutlu, Ozlem The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title | The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title_full | The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title_fullStr | The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title_full_unstemmed | The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title_short | The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases |
title_sort | effect of dysfunctional ubiquitin enzymes in the pathogenesis of most common diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503467/ https://www.ncbi.nlm.nih.gov/pubmed/32882786 http://dx.doi.org/10.3390/ijms21176335 |
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