Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics

High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of (68...

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Detalles Bibliográficos
Autores principales: Bendre, Shreya, Zhang, Zhengxing, Kuo, Hsiou-Ting, Rousseau, Julie, Zhang, Chengcheng, Merkens, Helen, Roxin, Áron, Bénard, François, Lin, Kuo-Shyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503470/
https://www.ncbi.nlm.nih.gov/pubmed/32854201
http://dx.doi.org/10.3390/molecules25173854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503470/
https://www.ncbi.nlm.nih.gov/pubmed/32854201
http://dx.doi.org/10.3390/molecules25173854

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