Cargando…

Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics

High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of (68...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bendre, Shreya, Zhang, Zhengxing, Kuo, Hsiou-Ting, Rousseau, Julie, Zhang, Chengcheng, Merkens, Helen, Roxin, Áron, Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503470/ https://www.ncbi.nlm.nih.gov/pubmed/32854201 http://dx.doi.org/10.3390/molecules25173854

Ejemplares similares

What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake
por: Kuo, Hsiou-Ting, et al.
Publicado: (2022)

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
por: Kuo, Hsiou-Ting, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies
por: Lau, Joseph, et al.
Publicado: (2022)

Synthesis and Evaluation of (99m)Tc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography
por: Lu, Kelly, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Three Novel (68)Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging
por: Verena, Arsyangela, et al.
Publicado: (2023)

Reducing the Kidney Uptake of High Contrast CXCR4 PET Imaging Agents via Linker Modifications
por: Kwon, Daniel, et al.
Publicado: (2022)

One-Step (18)F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
por: Kuo, Hsiou-Ting, et al.
Publicado: (2019)

(68)Ga-Labeled [Leu(13)ψThz(14)]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake
por: Wang, Lei, et al.
Publicado: (2022)

Novel (68)Ga-Labeled Pyridine-Based Fibroblast Activation Protein-Targeted Tracers with High Tumor-to-Background Contrast
por: Verena, Arsyangela, et al.
Publicado: (2023)

(68)Ga-Labeled [Thz(14)]Bombesin(7–14) Analogs: Promising GRPR-Targeting Agonist PET Tracers with Low Pancreas Uptake
por: Wang, Lei, et al.
Publicado: (2023)

Monosodium Glutamate Reduces (68)Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model
por: Rousseau, Etienne, et al.
Publicado: (2018)

Synthesis and Evaluation of (68)Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

Sulfatase-cleavable linkers for antibody-drug conjugates
por: Bargh, Jonathan D., et al.
Publicado: (2020)

Peroxide-cleavable linkers for antibody–drug conjugates
por: Ashman, Nicola, et al.
Publicado: (2023)

(18)F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2019)

Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue
por: Lau, Joseph, et al.
Publicado: (2019)

Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
por: Balamkundu, Seetharamsing, et al.
Publicado: (2023)

Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography
por: Dude, Iulia, et al.
Publicado: (2017)

Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple N-Methylations for Melanoma Imaging with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2020)

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation
por: Castañeda, Lourdes, et al.
Publicado: (2013)

Targeting Refractory Mantle Cell Lymphoma for Imaging and Therapy Using C-X-C Chemokine Receptor Type 4 Radioligands
por: Kwon, Daniel, et al.
Publicado: (2022)

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging
por: Stenton, Benjamin J., et al.
Publicado: (2018)

Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates
por: Aho, Aapo, et al.
Publicado: (2021)

Correction: Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation
por: Bahou, Calise, et al.
Publicado: (2022)

Synthesis and radiolabelling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers
por: Murce, Erika, et al.
Publicado: (2023)

Cleavable Cross-Linkers Redefined by a Novel MS(3)-Trigger Algorithm
por: Kolbowski, Lars, et al.
Publicado: (2023)

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers
por: Subramanian, Romesh R., et al.
Publicado: (2015)

Membrane protein channels equipped with a cleavable linker for inducing catalysis inside nanocompartments
por: Zartner, Luisa, et al.
Publicado: (2021)

Design, synthesis and evaluation of (18)F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging
por: Zhang, Zhengxing, et al.
Publicado: (2017)

Developing New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures
por: Yu, Clinton, et al.
Publicado: (2014)

Evaluation of (¹¹¹)In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers
por: Jodal, Andreas, et al.
Publicado: (2015)

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker
por: Prag, Hiran A., et al.
Publicado: (2020)

Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins
por: Cardella, Davide, et al.
Publicado: (2022)

Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK
por: Trachsel, Belinda, et al.
Publicado: (2023)

Molecular Imaging and Radionuclide Therapy of Melanoma Targeting the Melanocortin 1 Receptor
por: Zhang, Chengcheng, et al.
Publicado: (2017)

Reduction of the Renal Radioactivity of (111)In-DOTA-Labeled Antibody Fragments with a Linkage Cleaved by the Renal Brush Border Membrane Enzymes
por: Suzuki, Hiroyuki, et al.
Publicado: (2023)

Preclinical Melanoma Imaging with (68)Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET
por: Zhang, Chengcheng, et al.
Publicado: (2017)

A novel mass spectrometry-cleavable, phosphate-based enrichable and multi-targeting protein cross-linker
por: Huang, Rong, et al.
Publicado: (2019)

Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker
por: Vartak, Abhishek, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_li3k3hc206rvrpqob8m0bcv7du