A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor

Analgesic and anti-inflammatory properties mediated by the κ opioid receptor (KOR) have been reported for oxadiazole imidazodiazepines. Affinities determined by radioligand competition assays of more than seventy imidazodiazepines using cell homogenates from HEK293 cells that overexpress KOR, µ opio...

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Detalles Bibliográficos
Autores principales: Li, Guanguan, Nieman, Amanda N., Mian, Md Yeunus, Zahn, Nicolas M., Mikulsky, Brandon N., Poe, Michael M., Methuku, Kashi R., Liu, Yongfeng, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503500/
https://www.ncbi.nlm.nih.gov/pubmed/32854311
http://dx.doi.org/10.3390/molecules25173864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503500/
https://www.ncbi.nlm.nih.gov/pubmed/32854311
http://dx.doi.org/10.3390/molecules25173864

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