Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis

Herein, 15 phenylpiperazine 3-benzyl-5,5-dimethylhydantoin derivatives (1–15) were screened for modulatory activity towards Msr(A) efflux pump present in S. epidermidis bacteria. Synthesis, crystallographic analysis, biological studies in vitro and structure–activity relationship (SAR) analysis were...

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Detalles Bibliográficos
Autores principales: Witek, Karolina, Latacz, Gniewomir, Kaczor, Aneta, Czekajewska, Joanna, Żesławska, Ewa, Chudzik, Anna, Karczewska, Elżbieta, Nitek, Wojciech, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503621/
https://www.ncbi.nlm.nih.gov/pubmed/32825366
http://dx.doi.org/10.3390/molecules25173788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503621/
https://www.ncbi.nlm.nih.gov/pubmed/32825366
http://dx.doi.org/10.3390/molecules25173788

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