Asymmetric Synthesis of Tertiary α -Hydroxyketones by Enantioselective Decarboxylative Chlorination and Subsequent Nucleophilic Substitution

Chiral tertiary α-hydroxyketones were synthesized with high enantiopurity by asymmetric decarboxylative chlorination and subsequent nucleophilic substitution. We recently reported the asymmetric decarboxylative chlorination of β-ketocarboxylic acids in the presence of a chiral primary amine catalyst...

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Detalles Bibliográficos
Autores principales: Kam, Mei Kee, Sugiyama, Akira, Kawanishi, Ryouta, Shibatomi, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503659/
https://www.ncbi.nlm.nih.gov/pubmed/32867091
http://dx.doi.org/10.3390/molecules25173902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503659/
https://www.ncbi.nlm.nih.gov/pubmed/32867091
http://dx.doi.org/10.3390/molecules25173902

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