GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells

Due to its importance in the pathogenesis of oral squamous cell carcinoma (OSCC), the Hedgehog (HH) pathway is considered a potential therapeutic target. We investigated the effects of GANT61, a GLI inhibitor, on HH gene expression, as well as on metastatic OSCC cell proliferation and death. Followi...

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Detalles Bibliográficos
Autores principales: Bacelar Sacramento de Araújo, Taís, de Oliveira Siquara da Rocha, Leonardo, Torres Andion Vidal, Manuela, Cerqueira Coelho, Paulo Lucas, Galvão dos Reis, Mitermayer, Solano de Freitas Souza, Bruno, Botelho Pereira Soares, Milena, Almeida Pereira, Thiago, Della Coletta, Ricardo, Pereira Bezerra, Daniel, Borges Dias, Rosane, Araújo Gurgel Rocha, Clarissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503713/
https://www.ncbi.nlm.nih.gov/pubmed/32846867
http://dx.doi.org/10.3390/ijms21176076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503713/
https://www.ncbi.nlm.nih.gov/pubmed/32846867
http://dx.doi.org/10.3390/ijms21176076

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