Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity

In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of ATP. In many cancers, highly expressed pyruvate dehydrogenase kinase 1 (PDK1) reduces the activity of pyruvate dehydrogenase (PDH) by inducing the phosphorylation of its E1...

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Detalles Bibliográficos
Autores principales: Kwak, Choong-Hwan, Jin, Ling, Han, Jung Ho, Han, Chang Woo, Kim, Eonmi, Cho, MyoungLae, Chung, Tae-Wook, Bae, Sung-Jin, Jang, Se Bok, Ha, Ki-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504051/
https://www.ncbi.nlm.nih.gov/pubmed/32825675
http://dx.doi.org/10.3390/ijms21176021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504051/
https://www.ncbi.nlm.nih.gov/pubmed/32825675
http://dx.doi.org/10.3390/ijms21176021

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