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Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity

In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of ATP. In many cancers, highly expressed pyruvate dehydrogenase kinase 1 (PDK1) reduces the activity of pyruvate dehydrogenase (PDH) by inducing the phosphorylation of its E1...

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Detalles Bibliográficos
Autores principales:	Kwak, Choong-Hwan, Jin, Ling, Han, Jung Ho, Han, Chang Woo, Kim, Eonmi, Cho, MyoungLae, Chung, Tae-Wook, Bae, Sung-Jin, Jang, Se Bok, Ha, Ki-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504051/ https://www.ncbi.nlm.nih.gov/pubmed/32825675 http://dx.doi.org/10.3390/ijms21176021

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