Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines

From three previously identified antiplasmodial hit compounds (A–C) and inactive series (D), all based on a 2-trichloromethylquinazoline scaffold, we conducted a structure-activity relationship (SAR) study at position four of the quinazoline ring by synthesizing 42 novel derivatives bearing either a...

Descripción completa

Detalles Bibliográficos
Autores principales: Amrane, Dyhia, Gellis, Armand, Hutter, Sébastien, Prieri, Marion, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice, Primas, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504092/
https://www.ncbi.nlm.nih.gov/pubmed/32867402
http://dx.doi.org/10.3390/molecules25173929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504092/
https://www.ncbi.nlm.nih.gov/pubmed/32867402
http://dx.doi.org/10.3390/molecules25173929

Ejemplares similares